Foods, Free Full-Text
Por um escritor misterioso
Descrição
The research has demonstrated a synergistic anticancer effect of Seabuckthorn pulp oil (SBO) and the standard chemotherapy regimen Docetaxel (DTX) against two non-small cell lung cancer (NSCLC) cell lines: A549 and H23. The synergizing effect of an SBO and DTX combination was detected utilizing SRB assay and combination index (CI) approaches. Flow cytometry was carried out using fluorescent probes to measure cell cycle analysis by DNA content and reactive oxygen species (ROS) generation. Further, we demonstrated that the synergistic anticancer activity of SBO merged with DTX was achieved by caspase-independent autophagy and senescence induction. These changes were concomitant with increased generation of ROS production and microtubule-associated protein 1 light chain 3 (LC3) protein expression, G1-phase arrest, and enhanced senescence-associated β-galactosidase staining activity. Our data also demonstrated that SBO or DTX treatment groups solely upregulated the phosphorylation of ERK, which coincided with the induction of autophagy vacuoles and was functionally associated with ROS activation. Moreover, endogenous LC3 puncta staining was performed and monitored by confocal microscopy. Overall, these results suggest new mechanisms for the antitumor activity of SBO co-treated with DTX through triggering autophagic cell death and senescence against cancer cells as a result of sustained ERK phosphorylation and intracellular ROS production in NSCLC. In addition, we also highlight SBO as an alternative therapeutic option or adjunct therapeutic strategy in combination with chemotherapeutic agents in lung cancer therapy management.
21 Day Fix Meal Plan Vol. 13 (All Meals, All Brackets
This taste testing exploration chart helps children to engage with their food., Children who are picky eaters can benefit from food exploration to
Food Exploration Chart - No Text
Free Health Resources
Our Products
Low Fodmap Diet: What it Is, Uses & How to Follow
What Is Real Food?
Fast Food Nutrition Database - Colaboratory
Food Text Vector Art, Icons, and Graphics for Free Download
FRESKO Hands-Free Full Automatic Vacuum Sealer Machine V8 Pro – Fresko-kitchen
Consumers' growing appetite for natural foods: Perceptions towards the use of natural preservatives in fresh fruit - ScienceDirect
Foods December-1 2023 - Browse Articles
Supreme Pizza, 11 oz at Whole Foods Market
September Meal Plan - Family Food on the Table
Confronting Scarcity: Interactive Tucson-area food resource map – The Daily Wildcat
de
por adulto (o preço varia de acordo com o tamanho do grupo)